MMG-0358

CHF 120.00
In stock
AG-CR1-3630-M0011 mgCHF 120.00
AG-CR1-3630-M0055 mgCHF 480.00
 
More Information
Product Details
Synonyms 4-Chloro-2-(1H-1,2,3-triazol-5-yl)phenol
Product Type Chemical
Properties
Formula C8H6ClN3O
MW 195.6
CAS 1378976-02-3
Purity Chemicals ≥98% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO (20mM).
Identity Determined by NMR.
Other Product Data NOTE: Prepare a 20mM solution in pure anhydrous DMSO. Prior to performing biological experiments we recommend to make dilutions of the stock solution into aqueous buffers (1mM solution of MMG-0358 in a 95% buffer/5% DMSO mixture).
InChi Key NBDFMTBYKCBTSW-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor.
  • Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.
Product References
  1. Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)
  2. Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors: U.F. Roehrig, et al.; J. Med. Chem. 58, 9421 (2015) (Review)
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