35 CHF CHF 35.00
AG-CR1-3657-M0011 mgCHF 35.00
AG-CR1-3657-M0055 mgCHF 120.00
AG-CR1-3657-M02525 mgCHF 450.00
|Appearance||White to off-white solid.|
|Solubility||Soluble in DMSO (5mg/ml), ethanol (2mg/ml) or DMF (2mg/ml).|
|Identity||Determined by 1H-NMR.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Keep cool and dry.|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively.
- Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression.
- Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.
- A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288): A.L. Ashford, et al.; Biochem. J. 457, 43 (2014)