AZ191

CHF 35.00
In stock
AG-CR1-3657-M0011 mgCHF 35.00
AG-CR1-3657-M0055 mgCHF 120.00
AG-CR1-3657-M02525 mgCHF 450.00
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Product Details
Synonyms N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
Product Type Chemical
Properties
Formula

C24H27N7O

MW 429.5
CAS 1594092-37-1
Purity Chemicals ≥98%
Appearance White to off-white solid.
Solubility Soluble in DMSO (5mg/ml), ethanol (2mg/ml) or DMF (2mg/ml).
Identity Determined by 1H-NMR.
InChi Key ZYVXTMKTGDARKR-UHFFFAOYSA-N
Smiles CN1C2=C(C=CN=C2)C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively.
  • Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression.
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.
Product References
  1. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288): A.L. Ashford, et al.; Biochem. J. 457, 43 (2014)
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