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Ancell
anti-CD38 (human), mAb (AT1) (APC)
551
CHF
CHF 551.00
In stock
ANC-187-060120 testsCHF 551.00
Figure 1: Human Raji cells were incubated 45 min on ice with 80µl of anti-CD38/APC at a 1:50 dilution (10µg/ml). Cells were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 2.63 log10 fluorescent units when compared to a Mouse IgG1/APC Isotype control (ANC-278-060). Binding was blocked when cells were pre-incubated with 20µl of 0.5mg/ml anti-CD38 antibody (ANC-187-020).
| Product Details | |
|---|---|
| Synonyms | ADP-ribosyl Cyclase 1; Cyclic ADP-ribose Hydrolase 1; T10 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | AT1 |
| Isotype | Mouse IgG1κ |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Human T cell tumor cells: CEM. |
| Label/Conjugates | APC |
| Application |
Flow Cytometry (1:50) |
| Crossreactivity | Human |
| Specificity |
Recognizes human CD38. Crossreactive with cynlomolgus macaque CD38, and recognizes a reduction-sensitive epitope. |
| Purity Detail | Protein A and SEC purified. |
| Formulation | 50mM Sodium Phosphate pH 7.5, 500mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P28907 |
| Declaration | Manufactured by Ancell Corporation. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
Do not freeze. Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose. CD38 is involved in lymphocyte activation and adhesion to endothelium and has been identified as a counter-receptor of CD31.
Product References
- Anti-CD38 autoantibodies: Characterisation in new-onset Type I diabetes and latent autoimmune diabetes of the adult (LADA) and comparison with other islet autoantibodies: R. Mallone, et al.; Diabetologia 45, 1667 (2002)
- Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque: E. Ferrero, et al.; BMC Immunol. 5, 21 (2004)
- Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell–recruiting Antibody Optimized for Cytotoxicity and Cytokine Release: C.L. Zuch de Zafra, et al.; Clin. Cancer Res. 25, 3921 (2019)
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