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BX 795 (TBK Inhibitor)

CHF 231.00

In stock

BBL-5001-M0055 mgCHF 231.00

BBL-5001-M02525 mgCHF 499.00

More Information
Product Details
Synonyms	BX-795; BX795; TBK1 Inhibitor
Product Type	Chemical
Properties
Formula	C₂₃H₂₆IN₇O₂S
MW	591.5
CAS	702675-74-9
Purity Chemicals	≥97% (HPLC)
Appearance	White to off-white powder.
Solubility	Soluble in DMSO (25mg/ml).
InChi Key	VAVXGGRQQJZYBL-UHFFFAOYSA-N
Smiles	[H]N(CCCN(C(C1=CC=CS1)=O)[H])C2=C(I)C=NC(N([H])C3=CC(N(C(N4CCCC4)=O)[H])=CC=C3)=N2
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

BX 795 was originally described as a moderately potent inhibitor of PDK1 (IC50 = 111nM), but is more importantly, a dual inhibitor of TBK1 and IKKε (IC50’s = 6 and 41nM respectively). TBK1 and IKKε regulate the production of Type I interferons during bacterial and viral infection via phosphorylation of the transcription factor IRF3. It also inhibited of MARK, MLK, NUAK, AurB, and ERK83. Exhibited antitumor activity in human oral squamous cell carcinoma, pancreatic ductal adenocarcinoma, and Glioblastoma Multiforme. BX 795 has been used to enhance lentiviral transduction efficiency in human NK cells and human primary T cells for CAR-T cell therapy.

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