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BellBrook
BX 795 (TBK Inhibitor)
231
CHF
CHF 231.00
In stock
BBL-5001-M0055 mgCHF 231.00
BBL-5001-M02525 mgCHF 499.00
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| Product Details | |
|---|---|
| Synonyms | BX-795; BX795; TBK1 Inhibitor |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H26IN7O2S |
| MW | 591.5 |
| CAS | 702675-74-9 |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (25mg/ml). |
| InChi Key | VAVXGGRQQJZYBL-UHFFFAOYSA-N |
| Smiles | [H]N(CCCN(C(C1=CC=CS1)=O)[H])C2=C(I)C=NC(N([H])C3=CC(N(C(N4CCCC4)=O)[H])=CC=C3)=N2 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
BX 795 was originally described as a moderately potent inhibitor of PDK1 (IC50 = 111nM), but is more importantly, a dual inhibitor of TBK1 and IKKε (IC50’s = 6 and 41nM respectively). TBK1 and IKKε regulate the production of Type I interferons during bacterial and viral infection via phosphorylation of the transcription factor IRF3. It also inhibited of MARK, MLK, NUAK, AurB, and ERK83. Exhibited antitumor activity in human oral squamous cell carcinoma, pancreatic ductal adenocarcinoma, and Glioblastoma Multiforme. BX 795 has been used to enhance lentiviral transduction efficiency in human NK cells and human primary T cells for CAR-T cell therapy.
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