VEGF-A (pig) ELISA Kit

Vascular endothelial growth factor (VEGF-A or VEGF), also known as vascular permeability factor (VPF), has been discovered in 1983. It is a member of the VEGF family that includes in mammals placental growth factor (PLGF), VEGF-B, VEGF-C, and VEGF-D (also known as c-Fos-induced growth factor, FIGF). VEGF-A is a glycoprotein having several isoforms of 121 to 206 amino acids with a molecular weight from 33 kDa to 57kDa. It is a homodimer stabilised by hydrophobic interactions and by a disulphide bound. VEGF-A is produced by many cells like fetal tissu, hematopoietic stem cells, epidermal keratinocytes, podocytes of the renal glomerulus, cardiac myocytes, prostatic epithelium, and certain epithelial cells of the adrenal cortex and lung. The main function of the VEGF-A is the angionesis (formation of new capillaries from pre-existing vessels) during the embryogenesis or during re-building of the blood vessel after an injury. It has also some secondary functions in the chemotacxis of macrophages/granulocytes and in vasodilation (indirectly by NO release). Due to its main function, overexpression of VEGF-A causes various diseases including cancer. A05425