anti-RXRα (Retinoid X receptor α), mAb (3A2)

Retinoid X Receptor Alpha (RXRα) is a type of nuclear receptor that functions as a transcription factor. It plays a crucial role in regulating gene expression in response to ligands such as retinoids (derivatives of vitamin A) and other signaling molecules. Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRα forms homodimers (RXR-RXR) or heterodimers with other nuclear receptors like retinoic acid receptor (RAR), peroxisome proliferator-activated receptors (PPARs), liver X receptor (LXR) or vitamin D receptor (VDR). These dimeric complexes regulate genes involved in cell growth, differentiation, metabolism, and apoptosis. RXRα dysregulation has been linked to various diseases, including cancer, metabolic disorders (e.g., obesity, diabetes), cardiovascular diseases or neurological disorders.