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Bertin Bioreagent
anti-TRAP220, mAb (1A10)
As low as
777
CHF
CHF 777.00
In stock
Only %1 left
BRT-G01041-R100100 µlCHF 777.00
| Product Details | |
|---|---|
| Synonyms | MED1; Mediator Subunit 1; Mediator of RNA Polymerase II Transcription Subunit 1; Thyroid Hormone Receptor-associated Protein Complex 220 kDa Component; TRIP-2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 1A10 |
| Isotype | Mouse IgG1κ |
| Source/Host | Mouse |
| Immunogen/Antigen | Synthetic peptide. |
| Application | ELISA, Western Blot, Immunoprecipitation, Immunofluorescence. Recommended dilutions: 1/500-1/5000 |
| Specificity | Recognizes human TRAP220. |
| Formulation | Liquid. Does not contain any preservative. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Bertin Bioreagent |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
TRAP220 is a scaffold protein in the Mediator complex, helping recruit RNA polymerase II to target genes. TRAP220 specifically interacts with nuclear receptors such as thyroid hormone receptor (TR), retinoid X receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and estrogen receptor (ER). It enhances ligand-dependent transcription of these receptors. TRAP220 helps in histone modification, making DNA more accessible for transcription. TRAP220/MED1 is overexpressed in breast and prostate cancers, contributing to hormone-driven tumor growth. Since TRAP220 interacts with PPARs, it is involved in glucose metabolism and obesity-related pathways. Mutations in TRAP220 can lead to embryonic lethality and growth defects due to disrupted nuclear receptor signaling.