anti-TAF3 (formerly TAFII140), mAb (2F5)

TAF3 is a transcription cofactor and a component of the TFIID complex, which is essential for RNA polymerase II-dependent transcription initiation. It plays an important role in regulating gene expression and transcription initiation. TAF3 is a core subunit of TFIID, a multi-protein complex that recognizes core promoter regions and recruits RNA polymerase II to initiate transcription. TAF3 is involved in the assembly and stabilization of the TFIID complex, ensuring proper interaction between TFIID and other transcription factors. TAF3 participates in chromatin remodeling by recruiting coactivators and chromatin-modifying enzymes. TAF3 is critical for proper gene expression during development, influencing cell differentiation and embryonic growth. Altered expression or mutations in TAF3 may disrupt transcription and contribute to oncogenesis and tumor progression.