anti-TAF4 (formerly TAFII135), mAb (2B9)

TAF4 is a transcription cofactor and a key subunit of the TFIID complex, which is crucial for the initiation of RNA polymerase II-dependent transcription. It helps regulate gene expression by interacting with other components of the TFIID complex. TAF4 is a core component of the TFIID complex, which is responsible for promoter recognition and recruitment of RNA polymerase II to initiate transcription. TAF4 participates in chromatin remodeling, which is essential for transcription. By interacting with other coactivators and chromatin-modifying enzymes, it helps make DNA more accessible to the transcription machinery. TAF4 is essential for proper gene expression during development. It is particularly involved in embryonic development and tissue-specific gene regulation. Mutations or dysregulation of TAF4 can lead to defects in developmental processes and cell differentiation. Altered expression of TAF4 has been implicated in certain cancers. TAF4 mutations may be associated with neurodevelopmental diseases.