anti-TAF5, mAb (2D2)

TAF5 is a transcription cofactor and a key subunit of the TFIID complex, which is involved in RNA polymerase II-dependent transcription initiation. It plays a crucial role in gene expression regulation, primarily through its involvement in the formation and stability of the TFIID complex. TAF5 is an integral component of the TFIID complex, a multi-protein complex responsible for promoter recognition and the recruitment of RNA polymerase II for transcription initiation. TFIID helps recognize and bind to the core promoter elements (such as the TATA box) of genes, enabling the transcriptional machinery to initiate gene expression. TAF5 plays a role in chromatin remodeling by helping recruit chromatin-modifying enzymes to target genes. TAF5 helps regulate the transcription of specific genes during processes like cell differentiation and embryonic development. Abnormal expression of TAF5 may promote tumor growth and cancer progression by disrupting the balance of genes involved in cell proliferation and apoptosis.