N-Methyl-1-deoxynojirimycin

CHF 120.00
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BVT-0130-M0011 mgCHF 120.00
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Product Details
Synonyms N-Methyl-dNM; N-Methylmoranoline; MOR-14; 1,5-Dideoxy-1,5-(methylimino)-D-glucitol
Product Type Chemical
Properties
Formula

C7H15NO4

MW 177.2
CAS 69567-10-8
Source/Host Chemicals Isolated from Streptomyces sp.
Purity Chemicals ≥98% (HPLC, 1H-NMR)
Appearance White solid.
Solubility Soluble in DMSO or water.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
InChi Key AAKDPDFZMNYDLR-XZBKPIIZSA-N
Smiles CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • α-Glucosidase inhibitor.
  • Glucosidase I inhibitor (IC50=0.3μM), 10-fold more potent over 1-Deoxynojirimycin (dNM).
  • Inhibitor of glycoprotein processing.
  • Strong glycosyltransferase (GTF) inhibitor.
  • Angiogenesis inhibitor.
  • Reduces the size of myocardial infarcts.
Product References
  1. N-methyl-1-deoxynojirimycin, a novel inhibitor of glycoprotein processing, and its effect on fowl plague virus maturation: P.A. Romero, et al.; Virology 130, 238 (1983)
  2. Effect of N-methyl-1-deoxy-nojirimycin on the degradation of cellobiose by Cellulomonas cartalyticum: H. Sahm, et al.; Appl. Microbiol. Biotechnol. 20, 54 (1984)
  3. Purification by affinity chromatography of glucosidase 1, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligasaccharides: H. Hettkamp, et al.; Eur. J. Biochem. 142, 85 (1984)
  4. Comparison between 1-deoxynojirimycin and N-methyl-1-deoxynojirimycin as inhibitors of oligosaccharide processing in intestinal epithelial cells: P.A. Romero, et al.; Biochem. J. 226, 733 (1985)
  5. Different effects of glucosidase inhibitors 1-deoxynojirimycin, N-methyl-1-deoxynojirimycin and castanospermine on the glycosylation of rat alpha1-proteinase inhibitor and α1-acid glycoprotein: V. Gross, et al.; Biochem. J. 236, 853 (1986)
  6. Inhibition of myoblast fusion by the glucosidase inhibitor N-methyl-1-deoxynojirimycin, but not by the mannosidase inhibitor 1-deoxymannojirimycin: P.C. Holland, et al.; Biochem. J. 238, 335 (1986)
  7. The glycoprotein-processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin alter the adhesion phenotype of skeletal myoblasts: G.C. Trudel, et al.; Biochem. Cell Biol. 68, 1411 (1990)
  8. Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain: K. Shailubhai, et al.; J. Biol. Chem. 266, 16587 (1991)
  9. Subsite specificity of the active site of glucosyltransferases from Streptococcus sobrinus: K.S. Devulapalle & G. Mooser; J. Biol. Chem. 269, 11967 (1994)
  10. N-methyl-1-deoxynojirimycin (MOR-14), an α-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts: M. Arai, et al.; Circ. Res. 97, 1290 (1998)
  11. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction: Y. Nishida, et al.; Heart Vessels 15, 268 (2000)
  12. Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits: D.-J. Wu, et al.; Circ. J. 65, 673 (2001)
  13. Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an α-1,6-glucosidase inhibitor: M. Arai, et al.; Br. J. Pharmacol. 135, 635 (2001)
  14. Biological study of the angiogenesis inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin: Y. Zhao, et al.; Chem. Biol. Drug Des. 75, 570 (2010)
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