205 CHF CHF 205.00
BVT-0161-M0011 mgCHF 205.00
BVT-0161-M0055 mgCHF 710.00
|Synonyms||CTM; Chaetomin; NSC289491; BRN0077366|
|Source/Host Chemicals||Isolated from Chaetomium sp.|
|Purity Chemicals||≥90% (HPLC)|
|Appearance||Off-white to fawn solid.|
|Solubility||Soluble in DMSO, ethyl acetate or pyridine; fairly soluble in methanol or 100% ethanol; insoluble in water.|
|Identity||Determined by 1H-NMR.|
|Declaration||Manufactured by BioViotica.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Protect from moisture.
Protect from light when in solution.
Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
|Product Specification Sheet|
- Anticancer antibiotic.
- Inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α.
- Histone H3K9 methyltransferases G9a and Suv39h inhibitor.
- Tumor growth inhibitor.
- Angiogenesis inhibitor.
- Potent immunosuppressor.
- Antibacterial and antifungal.
- Strong inducer of retinal pigment epithelium (RPE).
- The structure of chetomin: A.G. McInnes, et al.; JACS 98, 6741 (1976)
- Effects of chetomin on growth and acidic fermentation products of rumen bacteria: W.C. Jen and G.A. Jones; Can. J. Microbiol. 29, 1399 (1983)
- Immunomodulatory constituents from an Ascomycete, Chaetomiumseminudum: H. Fujimoto, et al.; J. Nat. Prod. 67, 98 (2004)
- Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway: A.L. Kung, et al.; Cancer Cell 6, 33 (2004)
- Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells: A. Staab, et al.; BMC Cancer 7, 213 (2007)
- Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1α (HIF-1α) and p300 by a zinc ejection mechanism: K.M. Cook, et al.; J. Biol. Chem. 284, 26831 (2009)
- Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine: K. M. Wang, et al.; JACS 131, 18078 (2009)
- Up-regulation of pro-inflammatory genes as adaptation to hypoxia in MCF-7 cells and in human mammary invasive carcinoma microenvironment: M. Tafani, et al.; Cancer Sci. 101, 1014 (2010)
- Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines: M. Takahashi, et al., J. Antibiot. 65, 263 (2012)
- Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer: K.M. Reece, et al.; Mol. Cancer 13, 91 (2014)
- Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells: J. Maruotti, et al.; PNAS 112, 10950 (2015)
- Chetomin, targeting HIF-1a/p300 complex, exhibits antitumour activity in multiple myeloma: E. Viziteu, et al.; Br. J. Canc. 114, 519 (2016)
- Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction: J. Dewangan, et al.; BBRC 495, 1915 (2018)
- Screening of a growth inhibitor library of sarcoma cell lines to identify potent anti-cancer drugs: Z. Qiao & T. Kondo; Electrophoresis 63, 1 (2019)
- Chetomin, a Hsp90/HIF1a pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells: S. Min, et al.; Cancer Biol. Ther. 21, 698 (2020)