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BioViotica
(+)-Brefeldin A
55
CHF
CHF 55.00
In stock
BVT-0190-M0011 mgCHF 55.00
| Product Details | |
|---|---|
| Synonyms | Ascotoxin; Decumbin |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H24O4 |
| MW | 280.4 |
| Merck Index | 14: 1369 |
| CAS | 20350-15-6 |
| Source/Host Chemicals | Isolated from Eupenicillium brefeldianum. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in acetone, DMSO, methanol or ethyl acetate (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | KQNZDYYTLMIZCT-KQPMLPITSA-N |
| Smiles | [H][C@@]12C[C@@H](O)C[C@H]1\C=C\CCC[C@H](C)OC(=O)\C=C\[C@H]2O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Protein transport from ER to Golgi inhibitor [2, 3].
- ADP-ribosylation factor (Arf) inhibitor [6].
- Cytotoxic [1].
- Antibiotic [8].
- Antiviral [8].
- Apoptosis inducer [5].
- Antitumor compound [9].
- Intracellular collagen degradation inhibitor
- Reviews [4, 7, 8].
Product References
- Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
- Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986)
- Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988)
- Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review)
- Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996)
- Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF: J.B. Helms & J.E. Rothman; Nature 360,352 (1992)
- Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), (Review)
- Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective: V. Betina; Folia Microbiol. (Praha) 37, 3 (1992), (Review)
- The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro: D.E. Larsson, et al.; Anticancer Res. 30, 149 (2010)
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