Actinomycin X2

CHF 110.00
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BVT-0375-M0011 mgCHF 110.00
BVT-0375-M0055 mgCHF 325.00
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Product Details
Synonyms Actinomycin A5; Actinomycin B2; Actinomycin V; Actinomycin D, 3A-(4-oxo-L-proline); NSC175006
Product Type Chemical


MW 1269.4
CAS 18865-48-0
RTECS AU2010000
Source/Host Chemicals Isolated from Streptomyces sp.
Purity Chemicals ≥98% (HPLC)
Appearance Orange crystals.
Solubility Soluble in DMSO, methanol, acetone or chloroform.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Smiles [H][C@]12CCCN1C(=O)[C@H](NC(=O)[C@H](NC(=O)C1=C3N=C4C(OC3=C(C)C=C1)=C(C)C(=O)C(N)=C4C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@]3([H])N(CCC3=O)C(=O)[C@H](NC1=O)C(C)C)[C@@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution protect from light at -20°C.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Aniso-Actinomycin (4-Oxopro instead of Pro in the β-chain).
  • Antitumor and antiviral antibiotic.
  • Antituberculosis agent.
  • Has higher cytotoxicity towards cultured human leukemia (HL-60) cells than actinomycin D.
  • Apoptosis inducer. Forms a complex with DNA and blocks its biological activity.
Product References
  1. Actinomycin V as a Potent Differentiation Inducer of F5-5 Friend Leukemia Cells: H. Morioka, et al.; Agric. Biol. Chem. 49, 2835 (1985)
  2. Structure elucidation of a potent anti-MRSA antibiotic AM3, produced by Streptomyces sp.: Y. Lim, et al.; Agric. Chem. Biotech. 38, 516 (1995)
  3. Identification of endophytic Streptomyces sp. R-5 and analysis of its antimicrobial metabolites: M. Shimizu, et al.; J. Gen. Plant Pathol. 70, 66 (2004)
  4. The actinomycins: Anticancer agents from natural products: A. B. Mauger & H. Lackner; page 281, CRC Press (2005)
  5. Characterization of Streptomyces MITKK-103, a newly isolated Actinomycin X2-producer: K. Kurosawa, et al.; Appl. Microbiol. Biotechnol. 72, 145 (2006)
  6. A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity: C. Chen, et al.; Appl. Microbiol. Biotechnol. 95, 919 (2012)
  7. Characterization of Streptomyces padanus JAU4234, a producer of actinomycin X2, fungichromin, and a new polyene macrolide antibiotic: Z.-Q. Xiong, et al.; Appl. Environ. Microbiol. 78, 589 (2012)
  8. Purification and structure determination of three bioactive molecules from a newly isolated Streptomyces sp. AH 47: A. Hamza, et al.; Int. J. Curr. Res. 5, 1548 (2013)
  9. Apoptosis of human prostate cancer cells induced by marine actinomycin X2 through the mTOR pathway compounded by MiRNA144: J. Liu, et al.; Anticancer Drugs 27, 156 (2016)
  10. Identification, Bioactivity, and Productivity of Actinomycins from the Marine-Derived Streptomyces heliomycini: D. Wang, et al.; Front. Microbiol. 8, 1147 (2017)
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