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BioViotica
Venturicidin A
145
CHF
CHF 145.00
In stock
BVT-0454-M0011 mgCHF 145.00
| Product Details | |
|---|---|
| Synonyms | Aabomycin A1 |
| Product Type | Chemical |
| Properties | |
| Formula |
C41H67NO11 |
| MW | 750.0 |
| Merck Index | 14: 9947 |
| CAS | 33538-71-5 |
| RTECS | YX4556000 |
| Source/Host Chemicals | Isolated from Streptomyces aureofaciens. |
| Purity Chemicals | ≥98% (1H-NMR, HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, methanol, acetone or dichloromethane. Insoluble in hexane or water. |
| Identity | Determined by 1H-NMR, 13C-NMR and MS. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | HHQKNFDAEDTRJK-LIOWZGMGSA-N |
| Smiles | [H][C@@]1(C[C@@H](OC(N)=O)[C@H](O)[C@@H](C)O1)O[C@@H]1CCC\C=C(C)\[C@@]2([H])O[C@](O)(CC=C2C)CC(=O)O[C@H]([C@H](C)C[C@@H](C)[C@H](O)[C@H](C)C(=O)CC)[C@H](C)C[C@@H](C)\C=C\1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- 20-Membered macrolide glycoside.
- Antibiotic and antifungal agent.
- Shows antitrypanosomal and antimalarial activity.
- Potent inhibitor of mitochondrial and bacterial ATP synthase.
- Inhibitor of F1F0-ATPase.
- Na+-translocating ATP synthases inhibitor.
Product References
- Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961)
- Metabolic products of microorganismus. 102. The structure of venturicidin A and B: M. Brufani, et al.; Helv. Chim. Acta 55, 2329 (1972)
- The chemotherapy of rodent malaria, XXXI. The effect of some metabolic inhibitors upen chloroquine-induced pigment clumping (CIPC) in Plasmodium berghei: D. C. Warhurst, et al.; Ann. Trop. Med. Parasitol. 72, 203 (1978)
- Effects of inhibitors on mitochondrial adenosine triphosphatase of T. pyriformis ST.: M. D. Unitt, et al.; J. Gen. Microbiol. 126, 261 (1981)
- Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D. S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985)
- Identity of aabomycin A with venturicidins: H. Akita, et al.; Agric. Biol. Chem. 54, 2465 (1990)
- An attempt to discriminate catalytic and regulatory proton binding sites in membrane-bound, thiol-reduced chloroplast ATP: M. Valerio, et al.; Biochemistry 31, 4239 (1992)
- Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi & Y. Hatefi; J. Biol. Chem. 268, 6168 (1993)
- The prokaryotic thermophilic TF1-ATPase is functionally compatible with the eukaryotic CF0-part of the chloroplast ATP sythase: J. M. Galmiche, et al.; FEBS Lett. 338, 152 (1994)
- Modification of sulfhydryl groups in the g-subunit of chloroplast-coupling factor 1 affects the proton slip through the ATP synthase: Y. Evron, et al.; Plant Physiol. 115, 1549 (1997)
- Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites: K. Otoguro, et al.; J. Antibiot. 61, 372 (2008)
- A novel 11-kDa inhibitory subunit in the F1FO ATP synthase of Paracoccus denitrificans and related alpha-proteobacteria: E. Morales-Rios, et al.; FASEB J. 24, 599 (2010)
- Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2: K. Shaaban et al.; J. Antibiot. 67, 223 (2014)
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