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Cayman
Histone H3 Polyclonal Antibody
485
CHF
CHF 485.00
In stock
CAY-13781-500500 µgCHF 485.00
Product Details | |
---|---|
Product Type | Polyclonal Antibody |
Properties | |
Immunogen/Antigen | Recombinant Histone H3 Protein. |
Application | ELISA, FC, IP, WB |
Crossreactivity | Human |
Specificity | Recognizes human H3. |
Formulation | 500 µg protein A-purified IgG |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by Cayman Chemicals. |
Shipping and Handling | |
Shipping | BLUE ICE |
Long Term Storage | -20°C |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination. Histone H3 PTMs function as epigenetic regulators of gene transcription by affecting chromatin structure and providing binding sites for many transcription factors, thus regulating several cellular functions including gene expression, cell cycle, and DNA replication and repair. Differential methylation of histone H3 at various lysine residues is catalyzed by SET domain-containing methyltransferases and marks sites of transcriptional activation or repression.