Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Cayman
LL-37 Polyclonal Antibody
485
CHF
CHF 485.00
In stock
CAY-15637-11 eaCHF 485.00
| Product Details | |
|---|---|
| Synonyms | Antibacterial Protein LL-37 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Application | WB |
| Crossreactivity | Human |
| Specificity | Recognizes human LL-37. |
| Formulation | 500 µl of peptide-affinity purified IgG |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Cayman Chemicals. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
LL-37 is a cationic α-helical peptide expressed in human bone marrow, testis, granulocytes, gingival epithelium, and a variety of immune cells. It is produced by proteolytic cleavage of the cathelicidin human cationic antimicrobial protein of 18 kDa (hCAP18). LL-37 has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro. It functions as a chemoattractant for human monocytes, neutrophils, and T cells, and induces chemokine secretion from epithelial cells in infected tissues. LL-37 is a component of LPS-induced NETs produced from human neutrophils isolated from patients with systemic lupus erythrematosus (SLE) or individuals without SLE. It also enhances PMA- or S. aureus-induced formation of NETs.