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Cayman
Myeloperoxidase Monoclonal Antibody (Clone 2C8)
485
CHF
CHF 485.00
In stock
CAY-15638-11 eaCHF 485.00
Product Details | |
---|---|
Synonyms | MPO |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 2C8 |
Isotype | IgG2b |
Application | IF |
Crossreactivity |
Human Mouse |
Specificity | Recognizes human and mouse MPO. |
Formulation | 200 µg of affinity-purified IgG2b |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by Cayman Chemicals. |
Shipping and Handling | |
Shipping | BLUE ICE |
Long Term Storage | -20°C |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
Myeloperoxidase (MPO) is a heme-containing enzyme and the most abundant protein in polymorphonuclear leukocytes (PMNs). It is comprised of two subunits linked by a disulfide bridge with each subunit containing a light and a heavy polypeptide chain. It can oxidize a variety of substrates and catalyzes the formation of highly reactive (pseudo)hypohalous acids and radicals, including hypochlorous acid. MPO is stored in azurophilic granules of PMNs and is released from activated or necrotic PMNs, after which it can bind to and modify acidic serum proteins, as well as recruit additional PMNs. MPO also has roles in PMN apoptosis and antimicrobial defense systems, including neutrophil extracellular traps (NETs). MPO-deficient mice exhibit reduced survival in a polymicrobial sepsis model, increased susceptibility to experimental autoimmune encephalomyelitis (EAE), and increased atherosclerosis in mice also deficient in the LDL receptor and fed an atherogenic diet.