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Cayman
Citrullinated Histone H4 (human, recombinant)
839
CHF
CHF 839.00
In stock
CAY-17927-100100 µgCHF 839.00
| Product Details | |
|---|---|
| Product Type | Protein |
| Properties | |
| Sequence | Recombinant full-length (aa1-103) protein expressed in E. coli, citrullinated with human recombinant PAD4. |
| Purity | ≥80% (SDS-PAGE) |
| Formulation | A solution in PBS, pH 7.4 |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Cayman Chemicals. |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Long Term Storage | -80°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Histone H4 is one of four core histone proteins, the others being H3, H2B, and H2A, that are involved in the organization of DNA into chromatin. Histones are subject to a variety of posttranslational modifications, such as methylation, acetylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Histone H4 can be citrullinated at the arginine residue at position 3 (H4R3) by protein arginine deiminase 4. Citrullination of H4R3 increases in U2OS cells following induction of DNA damage by adriamycin and is localized near fragmented nuclei. H4R3 citrullination is associated with smaller tumor size and inversely associated with p53 levels in tumor tissue samples derived from patients with non-small cell lung cancer (NSCLC).