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Cayman
Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody
616
CHF
CHF 616.00
In stock
CAY-17939-100100 µgCHF 616.00
Product Details | |
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Product Type | Monoclonal Antibody |
Properties | |
Clone | 11D3 |
Isotype | IgG1 |
Immunogen/Antigen | Histone 3 peptide with citrullinations at R2, R8, and R17. |
Application | ELISA, WB |
Crossreactivity | Human |
Specificity | Recognizes Histone H3 (Citrullinated R2 + R8 + R17). |
Formulation | 100 µg protein G-purified IgG |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by Cayman Chemicals. |
Shipping and Handling | |
Shipping | BLUE ICE |
Long Term Storage | -20°C |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications, including citrullination. Histone H3 is subject to citrullination of arginine residues by peptidyl arginine deiminase 4 (PAD4) at positions 2, 8, 17 and 26, and this citrullination blocks methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and induces transcriptional repression of target genes. Citrullinated histone H3 is a component of neutrophil extracellular traps (NETs) that acts as an autoantigen to induce production of anti-citrullinated protein antibodies associated with various diseases such as sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma.