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Cayman
LY2409881
49
CHF
CHF 49.00
In stock
CAY-18774-11 mgCHF 49.00
CAY-18774-55 mgCHF 120.00
CAY-18774-1010 mgCHF 214.00
CAY-18774-2525 mgCHF 470.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C24H29ClN6OS . 3HCl |
| MW | 594.4 |
| CAS | 946518-60-1 |
| Purity Chemicals | ≥98% |
| Appearance | A crystalline solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | IEXCRLAGBWKVPW-UHFFFAOYSA-N |
| Smiles | O=C(NC1CC1)C2=C(C=C(C3=C(Cl)C=NC(NCCCN4CCN(C)CC4)=N3)S5)C5=CC=C2.Cl.Cl.Cl |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
LY2409881 is a selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM). It inhibits IKK1 and other common kinases at ≥10-fold higher concentrations. LY2409881 has been shown to suppress constitutively activated NF-κB and to induce apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma both as a single agent and in combination with histone deacetylase inhibitors.