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Cayman
CdnP (Mycobacterium tuberculosis strain ATCC 25618/H37Rv recombinant)
610
CHF
CHF 610.00
In stock
CAY-22809-100100 µgCHF 610.00
| Product Details | |
|---|---|
| Synonyms | 3'(2'),5'-Bisphosphate Nucleotidase; 3'-Phosphoadenosine 5'-phosphate Phosphatase; Bifunctional Oligoribonuclease and PAP Phosphatase NrnA; Cyclic di-NMP Phosphodiesterase; EC: 31.13.7; PAP Phosphatase; Rv2837c |
| Product Type | Protein |
| Properties | |
| Sequence | Active recombinant M. tuberculosis strain ATCC 25618/H37Rv N-terminal Trx-, His-, and S-tagged CdnP expressed in E. coli. |
| Purity | ≥70% (SDS-PAGE) |
| Formulation | 50 mM HEPES, pH 8.0, with 150 mM sodium chloride |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Cayman Chemicals. |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Long Term Storage | -80°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cyclic dinucleotide phosphodiesterase (CdnP) is a soluble phosphodiesterase involved in regulating cyclic dinucleotide signaling during intracellular infections of M. tuberculosis. It is composed of an N-terminal Asp-His-His (DHH) domain and a C-terminal DHH-associated (DHHA1) domain that catalyze the hydrolysis of cyclic dinucleotides. CdnP hydrolyzes a variety of cyclic dinucleotides, including cyclic di-AMP, cyclic di-GMP, and 2'3'-cGAMP, which decreases their recognition by the stimulator of interferon genes (STING), a key mediator in the host innate immune response.