STING R232 variant (human, recombinant)

Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The H232 variant of STING is found at a 13.7% frequency in the 1000 Genome Project. The SNP variant R232 is the most common variant in the human population, found at a frequency of 57.9%. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M and V155M, lead to constitutive activation and enhancement of the type I IFN response.