Cayman

cGAS Monoclonal Antibody (Clone 5G10)

CHF 776.00
In stock
CAY-23853-300300 µgCHF 776.00
 
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Product Details
Synonyms C6orf150; cGAMP synthase; Cyclic GMP-AMP synthase; h-cGAS; Mab-21 domain-containing protein 1; MB21D1
Product Type Monoclonal Antibody
Properties
Clone 5G10
Isotype IgG2A
Immunogen/Antigen Full length human recombinant protein.
Application IF, IP, WB
Crossreactivity Human
Specificity Recognizes human cGAS.
Formulation 300 µg of protein G-purified IgG
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Cayman Chemicals.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
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Description
Cyclic GMP-AMP (cGAMP) synthase is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway. In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. In vivo, cGAS-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.
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