Cayman

Citrullinated LL-37 Monoclonal Antibody (Clone 6A8)

CHF 561.00
In stock
CAY-26739-300300 µgCHF 561.00
 
More Information
Product Details
Synonyms Antibacterial Peptide LL-37; Antibacterial Protein LL-37
Product Type Monoclonal Antibody
Properties
Clone 6A8
Isotype IgG1
Immunogen/Antigen Citrullinated human LL-37 peptide.
Application ELISA, WB
Crossreactivity Human
Specificity Recognizes human citrullinated LL-37.
Formulation 300 µg of protein G-purified monoclonal antibody
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Cayman Chemicals.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description
LL-37 is a cationic α-helical peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and a variety of immune cells. It has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro. LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities. Citrullinated, unlike native, LL-37 does not prevent mortality in a mouse model of D-galactosamine-sensitized endotoxic shock. Citrullinated LL-37 has been found in neutrophil extracellular traps (NETs), as well as the serum of patients with rheumatoid arthritis (RA) and individuals without RA.
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.