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Cayman
G150
169
CHF
CHF 169.00
In stock
CAY-28318-11 mgCHF 169.00
CAY-28318-55 mgCHF 627.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C18H16Cl2N4O2 |
| MW | 391.3 |
| CAS | 2369751-30-2 |
| Purity Chemicals | ≥95% |
| Appearance | A crystalline solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VVUOUIPXYFIWLE-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C2=CC=C(N)N=C2)=C3C(NC4=C3CN(C(CO)=O)CC4)=C1Cl |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A cGAS inhibitor (IC50 = 10.2 nM for the human enzyme); selective for human cGAS over mouse cGAS (IC50 = 25,000 nM); inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but not LPS-induced expresssion of TNF or poly(I:C)-induced rRNA degradation in the same cells at 10 µM.