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Cayman
IM-93
49
CHF
CHF 49.00
In stock
CAY-28794-11 mgCHF 49.00
CAY-28794-55 mgCHF 214.00
CAY-28794-1010 mgCHF 374.00
CAY-28794-2525 mgCHF 821.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C21H28N4O2 |
| MW | 368.5 |
| CAS | 1173657-73-2 |
| Purity Chemicals | ≥98% |
| Appearance | A crystalline solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | DKUCOVGKUCYQLB-UHFFFAOYSA-N |
| Smiles | O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3NCCCN(C)C)N(C(C)C)C3=O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A dual inhibitor of ferroptosis and NETosis; inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases PMA-induced NETosis in isolated human peripheral blood neutrophils at 1.6-25 µM; inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 µM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells at 25 µM.