Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Cayman
GSK8612
103
CHF
CHF 103.00
In stock
CAY-28813-55 mgCHF 103.00
CAY-28813-1010 mgCHF 185.00
CAY-28813-2525 mgCHF 410.00
CAY-28813-5050 mgCHF 613.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C17H17BrF3N7O2S |
| MW | 520.3 |
| CAS | 2361659-62-1 |
| Purity Chemicals | ≥95% |
| Appearance | A solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | FFPHMUIGESPOTK-UHFFFAOYSA-N |
| Smiles | NS(C1=CC=C(CNC2=C(Br)C=NC(NC3=CN(CC(F)(F)F)N=C3C)=N2)C=C1)(=O)=O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A TBK1 inhibitor (IC50 = 158 nM); selective for TBK1 over a panel of 285 kinases; inhibits IFN-α release in poly(I:C)-stimulated isolated human PBMCs (IC50 = 794 nM); inhibits IFN-β secretion in THP-1 cells stimulated with dsDNA-containing baculovirus or cGAMP (IC50s = 1,258 and 501 nM, respectively); reduces tumor volume and increases the number of tumor-infiltrating CD8+ T cells in immunocompetent, but not immunodeficient, mice in a model of carbon tetrachloride-induced HCC at 5 mg/kg.