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Cayman
MSA-2
49
CHF
CHF 49.00
In stock
CAY-30140-11 mgCHF 49.00
CAY-30140-55 mgCHF 154.00
CAY-30140-1010 mgCHF 236.00
| Product Details | |
|---|---|
| Synonyms | 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid |
| Product Type | Chemical |
| Properties | |
| Formula | C14H14O5S |
| MW | 294.3 |
| CAS | 129425-81-6 |
| Purity Chemicals | ≥98% |
| Appearance | A crystalline solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | APCLRHPWFCQIMG-UHFFFAOYSA-N |
| Smiles | COC1=C(OC)C=C(C=C(C(CCC(O)=O)=O)S2)C2=C1 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A STING agonist; binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 µM, respectively); induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2'3'-cGAMP at 30 ?M; reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression at 450 µg, intratumorally, and 50 mg/kg, s.c.; acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.