Cayman

PAD4 (human, recombinant; mammalian expressed)

CHF 776.00
In stock
CAY-32834-5050 µgCHF 776.00
 
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Product Details
Synonyms PADI4; PADI5; Peptidylarginine Deiminase 4; Protein Arginine Deiminase Type 4; Protein Arginine Deiminase Type IV
Product Type Protein
Properties
Sequence Recombinant N-terminal His-tagged human PAD4 expressed in HEK293 cells.
Purity ≥90% (SDS-PAGE)
Formulation 50 mM HEPES, pH 8.0, 300 mM sodium chloride, 1 mM DTT, and 10% glycerol
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Cayman Chemicals.
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Long Term Storage -80°C
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Description
Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain, liver, lung, and kidney. PAD4 has a key role in NETosis, a lytic form of cell death characterized by the release of neutrophil extracellular traps (NETs). Upon neutrophil activation, PAD4 translocates to the nucleus where it citrullinates histones, initiating chromatin decondensation and the release of NETs. Neutrophils isolated from Pad4-/- mice exhibit decreased citrullination of histone H3 under both basal and LPS-stimulated conditions and are defective for NET formation in response to stimulation with LPS.
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