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Cayman
PAD4 Polyclonal Antibody
255
CHF
CHF 255.00
In stock
CAY-33914-100100 µlCHF 255.00
| Product Details | |
|---|---|
| Synonyms | PADI4; PADI5; Peptidylarginine Deiminase 4; Protein Arginine Deiminase Type 4; Protein Arginine Deiminase Type IV |
| Product Type | Polyclonal Antibody |
| Properties | |
| Immunogen/Antigen | Recombinant human PAD4 protein. |
| Application | ELISA |
| Crossreactivity | Human |
| Specificity | Recognizes human PAD4. |
| Formulation | 100, 200, or 400 µl of protein A-purified polyclonal antibody |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Cayman Chemicals. |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Long Term Storage | -80°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain, liver, lung, and kidney. PAD4 has a key role in NETosis, a lytic form of cell death characterized by the release of neutrophil extracellular traps (NETs). Upon neutrophil activation, PAD4 translocates to the nucleus where it citrullinates histones, initiating chromatin decondensation and the release of NETs. Neutrophils isolated from Pad4-/- mice exhibit decreased citrullination of histone H3 under both basal and LPS-stimulated conditions and are defective for NET formation in response to stimulation with LPS.