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Cayman
DCPIB
112
CHF
CHF 112.00
In stock
CAY-34064-55 mgCHF 112.00
CAY-34064-1010 mgCHF 202.00
CAY-34064-2525 mgCHF 444.00
CAY-34064-5050 mgCHF 773.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C22H28Cl2O4 |
| MW | 427.4 |
| CAS | 82749-70-0 |
| Purity Chemicals | ≥98% |
| Appearance | A crystalline solid |
| Declaration | Manufactured by Cayman Chemicals. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KHKGTPJPBOQECW-UHFFFAOYSA-N |
| Smiles | O=C(CCCOC1=C(Cl)C(Cl)=C(C(C(CCCC)(C2CCCC2)C3)=O)C3=C1)O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A VRAC inhibitor; inhibits ICl, swell in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM); inhibits LRRC8A (IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in TIME cells at 20 µM; inhibits K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively); activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels at 10 µM; intracisternal administration reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by MCAO at 20 µg/kg.