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Cayman
Citrullinated Histone H3 (Clone 11D3) ELISA Kit
884
CHF
CHF 884.00
In stock
CAY-501620-9696 wellsCHF 884.00
| Product Details | |
|---|---|
| Synonyms | CitH3 (Clone 11D3) EIA Kit |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Sensitivity | 0.1 ng/ml |
| Range | 0.15-10 ng/ml |
| Detection Type | Colorimetric |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Cayman Chemicals. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Documents | |
| Manual | No |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Histone H3 is citrullinated by peptidylarginine deiminase 4 (PAD4) at residues R2, R8, and R17 during the processes of epigenetic chromatin remodeling and neutrophil extracellular trap (NET) formation. In vitro, citrullinated H3 (CitH3) is released from neutrophils that have been stimulated with calcium ionophore during the process of NETosis, and can be freed from NETs by treatment with nuclease. The measurement of CitH3, either in cell lysates or released during NETosis can be used as a functional readout of pharmacological PAD inhibition.