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Cayman
cGAS Inhibitor Screening Assay Kit
950
CHF
CHF 950.00
In stock
CAY-701930-9696 wellsCHF 950.00
CAY-701930-96S96 wellsCHF 950.00
| Product Details | |
|---|---|
| Synonyms | 2'3'-cGAMP Synthase; C6orf150; Cyclic GMP-AMP Synthase |
| Product Type | Kit |
| Properties | |
| Application Set | Compound Screening |
| Sensitivity | 48.4 pM |
| Range | 4.6-10,000 pM |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by Cayman Chemicals. |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Long Term Storage | -80°C |
| Documents | |
| Manual | No |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Cayman's cGAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human cGAS, which is a cytosolic dsDNA sensor that detects microbial pathogens. The assay directly measures 2'3'-cGAMP produced by cGAS in the presence of DNA, ATP, and GTP. The cyclic dinucleotide product of that reaction is quantified via ELISA using a 2'3'-cGAMP-specific antiserum. The cGAS inhibitor CU-76 is included as a positive control. The ELISA portion of Cayman's cGAS Inhibitor Screening Assay Kit is a competitive assay with a range of 4.57-10,000 pM, a midpoint of approximately 300 pM (50% B/B0), and a sensitivity (80% B/B0) of approximately 50 pM.