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Chemodex
L-Azetidine-2-carboxylic acid
As low as
77
CHF
CHF 77.00
In stock
Only %1 left
CDX-A0051-M250250 mgCHF 77.00
CDX-A0051-G0011 gCHF 155.00
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| Product Details | |
|---|---|
| Synonyms | A2C; LACA; L-AZC; L-Aze; L-A-2-C; (S)-Azetidine-2-carboxylic acid; (-)-Azetidinecarboxylic acid |
| Product Type | Chemical |
| Properties | |
| Formula | C4H7NO2 |
| MW | 101.1 |
| CAS | 2133-34-8 |
| RTECS | CM4310500 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (TLC) |
| Appearance | White to light beige to brown powder. |
| Solubility | Slightly soluble in water or DMF. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | IADUEWIQBXOCDZ-VKHMYHEASA-N |
| Smiles | OC([C@@H]1CCN1)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
L-Azetidine-2-carboxylic acid (Aze) is a non-proteinogenic amino acid derivative of L-proline that has been found in C. majalis and has diverse biological activities. It is widely used in biochemical and molecular biology research. It is incorporated into proteins in place of proline, inducing conformational changes that help study protein folding, stability, and misfolding-related diseases. Aze is also used as a versatile building block in the synthesis of constrained peptides and peptidomimetics, making it valuable for probing structure-function relationships and designing bioactive molecules. L-Azetidine-2-carboxylic acid is an inhibitor of collagen synthesis that is anti-angiogenic. It destabilizes the collagen triple helix and reduces the extracellular localization of collagen. It is toxic to a variety of bacteria and can induce cell death through both apoptotic and necrotic cell death in mammalian cells.
Product References
(1) M.G. Joneja; Teratology 23, 365 (1981) | (2) W.D. Klohs, et al.; J. Natl. Cancer Inst. 75, 353 (1985) | (3) A. Zagari, et al.; Biopolymers 30, 951 (1990) | (4) T.M.H. Bach & H. Takagi; Appl. Microbiol. Biotechnol. 97, 6623 (2013) | (5) K. Tabara, et al.; Methods Mol. Biol. 1691, 223 (2018) | (6) K. Samardzic & K.J. Rodgers; Amino Acids 51, 1221 (2019) | (7) K.J. Rodgers, et al.; Toxicol. 510, 153999 (2025)