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Chemodex
3,5-Dimethyl-NAPQI
258
CHF
CHF 258.00
In stock
CDX-A0163-M01010 mgCHF 258.00
CDX-A0163-M02525 mgCHF 516.00
| Product Details | |
|---|---|
| Synonyms | NA-3,5-Bqi; N-Acetyl-3,5-dimethyl-4-benzoquinone imine |
| Product Type | Chemical |
| Properties | |
| Formula | C10H11NO2 |
| MW | 177.2 |
| CAS | 74827-85-3 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95.0% (HPLC) |
| Appearance | Orange powder. |
| Solubility | Soluble in chloroform. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VUPORYDINWWWKZ-UHFFFAOYSA-N |
| Smiles | CC(=O)N=C1C=C(C)C(=O)C(C)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Metabolite. Oxidizing analog of N-acetyl-p-benzoquinone imine (NAPQI), a toxic metabolite of acetaminophen (paracetamol). Primarily oxidizes protein thiols. Shows cytotoxic properties, through disruption of intracellular Ca2+ homeostasis. Compound can be used as analytical reference material.
Product References
(1) R. van de Straat, et al.; Biochem. Pharmacol. 36, 2065 (1987) | (2) L. Rossi, et al.; Mol. Pharmacol. 34, 674 (1988) | (3) P. Nicotera, et al.; Chem. Res. Toxicol. 2, 46 (1989) | (4) P. Nicotera, et al.; Arch. Biochem. Biophys. 283, 200 (1990)