3,5-Dimethyl-NAPQI

CHF 242.00
In stock
CDX-A0163-M01010 mgCHF 242.00
CDX-A0163-M02525 mgCHF 485.00
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Product Details
Synonyms NA-3,5-Bqi; N-Acetyl-3,5-dimethyl-4-benzoquinone imine
Product Type Chemical
Properties
Formula C10H11NO2
MW 177.2
CAS 74827-85-3
Source/Host Chemicals Synthetic
Purity Chemicals ≥95.0% (HPLC)
Appearance Orange powder.
Solubility Soluble in chloroform.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key VUPORYDINWWWKZ-UHFFFAOYSA-N
Smiles CC(=O)N=C1C=C(C)C(=O)C(C)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Metabolite. Oxidizing analog of N-acetyl-p-benzoquinone imine (NAPQI), a toxic metabolite of acetaminophen (paracetamol). Primarily oxidizes protein thiols. Shows cytotoxic properties, through disruption of intracellular Ca2+ homeostasis. Compound can be used as analytical reference material.

Product References

(1) R. van de Straat, et al.; Biochem. Pharmacol. 36, 2065 (1987) | (2) L. Rossi, et al.; Mol. Pharmacol. 34, 674 (1988) | (3) P. Nicotera, et al.; Chem. Res. Toxicol. 2, 46 (1989) | (4) P. Nicotera, et al.; Arch. Biochem. Biophys. 283, 200 (1990)

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