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Chemodex
Amikacin disulfate salt
155
CHF
CHF 155.00
In stock
CDX-A0286-G0011 gCHF 155.00
CDX-A0286-G0055 gCHF 464.00
| Product Details | |
|---|---|
| Synonyms | Amikacin disulfate; Biodacyn; Selemycin; Amiglyde; BB-K 8; Novamin; Amikin |
| Product Type | Chemical |
| Properties | |
| Formula | C22H43N5O13 . 2H2SO4 |
| MW | 781.76 |
| CAS | 39831-55-5 |
| RTECS | WK1961200 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (NMR) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (50mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | FXKSEJFHKVNEFI-GCZBSULCSA-N |
| Smiles | OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]([C@@H]([C@H]1N)O[C@H]([C@@H]([C@H]2O)O)O[C@H](CN)[C@H]2O)[C@H]([C@@H](C1)N([H])C([C@H](CCN)O)=O)O[C@H]([C@@H]([C@H]3N)O)O[C@H](CO)[C@H]3O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection.
Product References
[1] H. Kawaguchi, et al.; J. Antibiot. 25, 695 (1972) | [2] P.K. Yu, et al.; Antimicrob. Agents Chemother. 4, 133 (1973) | [3] D. Zaske & K. Crossley; Minn. Med. 61, 123 (1978) (Review) | [4] F.D. Pien & P.W. Ho; Am. J. Hosp. Pharm. 38, 981 (1981) (Review) | [5] A.M. Ristuccia & B.A.Cunha; Ther. Drug Monit. 7, 12 (1985) (Review) | [6] M.S. Ramirez & M.E. Tolmasky; Molecules 22, 2267 (2017) (Review)