N4-Acetylsulfamethoxazole

Specifications / Handling

More Information
Product Details
Synonyms	N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide; Sulfisomezole-N4-acetate; BRN 0285801; STX 606
Product Type	Chemical
Properties
Formula	C₁₂H₁₃N₃O₄S
MW	295.3
CAS	21312-10-7
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥99% (HPLC)
Appearance	White to off-white powder or crystals.
Solubility	Soluble in chloroform.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	GXPIUNZCALHVBA-UHFFFAOYSA-N
Smiles	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NOC(C)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

This is a metabolite of the sulfonamide bacteriostatic antibiotic sulfamethoxazole. Sulfamethoxazole is metabolized via acetylation, catalyzed by liver extramitochondrial N-acetyl transferases. Acetyl-Sulfamethoxazole is excreted in urine. Both compounds can be used as a probe for the molecular percentage enrichement of liver extramitochondrial acetyl-CoA. Acetyl-Sulfamethoxazole can also be used as a reference for sulfamethoxazole impurity and waste determination.

Product References

(1) T.B. Vree, et al.; Clin. Pharmacokinet. 3, 319 (1978) | (2) R.M. Hutabarat, et al.; Clin. Pharmacol. Ther. 49, 402 (1991) | (3) T. Heberer, et al.; Toxicol. Lett. 131, 5 (2002) | (4) T.A. Larsen, et al.; J. Biotechnol. 113, 295 (2004) | (5) K. Stein, et al.; Environ. Sci. Technol. 42, 6415 (2008)

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