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Chemodex
Aluminon
61
CHF
CHF 61.00
In stock
CDX-A0293-G02525 gCHF 61.00
| Product Details | |
|---|---|
| Synonyms | Aurintricarboxylic acid ammonium salt; ATA; Ammonium aurintricarboxylate |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H14O9 . 3NH3 |
| MW | 422.3 . 51.1 |
| CAS | 569-58-4 |
| RTECS | GU4800000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | n.a. |
| Appearance | Dark red to brown powder. |
| Solubility | Soluble in DMSO or water (50mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | AIPNSHNRCQOTRI-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(/C(C2=CC=C(O)C(C([O-])=O)=C2)=C3C=C(C([O-])=O)C(C=C/3)=O)C=C1C([O-])=O.[NH4+].[NH4+].[NH4+] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Aluminon, the triammonium salt of aurintricarboxylic acid, is a dye commonly used to detect the presence of the aluminium ion in an aqueous solution. In addition to its use in qualitative inorganic analysis, aluminon has applications in pigment production. It forms brilliantly colored lake pigments with aluminum, chromium, iron and beryllium. Spectral data: AL-Complex Absorbance at ~525nm. Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of RNA-directed DNA polymerase and topoisomerase II. Angiogenesis inhibitor. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. It is neuroprotective maybe due to calpain inhibition. It has antiviral properties, is a potent phosphofructokinase inhibitor, a TWEAK-Fn14 signaling pathway inhibitor and a DNMT1 inhibitor.
Product References
(1) G.R. Berube, et al.; Stain Technol. 39, 337 (1964) | (2) M.L. Stewart, et al.; PNAS 68, 97 (1971) (3) Blumenthal & T.A. Landers; BBRC 55, 680 (1973) | (4) J.F. Givens & K.F. Manly; Nucleic Acids Res. 3, 405 (1976) | (5) R.G. Gonzalez, et al.; Biochemistry 19, 4299 (1980) | (6) R.A Clark & G.L. Krueger; J. Histochem. Cytochem. 33, 729 (1985) (Review) | (7) J. Balzarini, et al.; BBRC 136, 64 (1986) | (8) S.A. McCune, et al.; Biochem. J. 259, 925 (1989) | (9) D. Schols, et al.; PNAS 86, 3322 (1989) | (10) I. Oberbaumer & C. Speth; Anal. Biochem. 185, 77 (1990) | (11) A.R. Gagliardi & D.C. Collins; Anticancer Res. 14, 475 (1994) | (12) D.R. Catchpoole & B.W. Stewart; Anticancer Res. 14, 853 (1994) | (13) Y. Benchokroun, et al.; Biochem. Pharmacol. 49, 305 (1995) | (14) A. Posner, et al.; Biochem. Mol. Biol. Int. 36, 291 (1995) | (15) C.J. Tsi, et al.; Mol. Pharmacol. 62, 90 (2002) | (16) C.W. Chen, et al.; Br. J. Pharmacol. 137, 1011 (2002) | (17) R. He, et al.; BBRC 320, 1199 (2004) | (18) H. Cho, et al.; Mol. Cells 18, 46 (2004) | (19) Y. Chen, et al.; Antivir. Chem. Chemother. 20, 19 (2009) | (20) J. Yoo, et al.; Adv. Protein Chem. Struct. Biol. 87, 219 (2012) (Review) | (21) A. Roos, et al.; Oncotarget 8, 12234 (2017)