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Chemodex
Apigenin
61
CHF
CHF 61.00
In stock
CDX-A0438-M02525 mgCHF 61.00
CDX-A0438-M100100 mgCHF 177.00
| Product Details | |
|---|---|
| Synonyms | Chamomile; Flavone; NSC 83244; Versulin; 4',5,7-Trihydroxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone |
| Product Type | Chemical |
| Properties | |
| Formula | C15H10O5 |
| MW | 270.24 |
| CAS | 520-36-5 |
| RTECS | LK9276000 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Yellow to brown powder. |
| Solubility | Soluble in DMSO (10mg/ml) or DMF (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
| Smiles | OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Shown to selectively inhibits chymotrypsin-like and trypsin-like proteasome catalytic activity.
Product References
(1) Y.C. Liang, et al.; Carcinogenesis 20, 1945 (1999) | (2) D.H. Song, et al.; J. Biol. Chem. 275, 23790 (2000) | (3) J. Shen, et al.; J. Immunol. 167, 4919 (2001) | (4) G.M. Raso, et al.; Life Sci. 68, 921 (2001) | (5) M. Yamada, et al.; PNAS 102, 7736 (2005) | (6) M.B. Ujiki, et al.; Mol. Cancer 5, 76 (2006) | (7) J. Fang, et al.; Carcinogenesis 28, 858 (2006) | (8) Y.-X. Wu & X. Fang; Planta Med. 76, 128 (2010) | (9) X. Yan, et al.; Cell Biosci. 7, 50 (2017) (Review) | (10) S.F. Nabavi, et al.; Pharmacol. Res. 128, 359 (2018) (Review) | (11) J. Madunic, et al.; Cancer Lett. 413, 11 (2018) (Review)