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Chemodex
Aloin
115
CHF
CHF 115.00
In stock
CDX-A0527-M05050 mgCHF 115.00
CDX-A0527-M100100 mgCHF 197.00
| Product Details | |
|---|---|
| Synonyms | 1,8-Dihydroxy-10-(β-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone; Aloin A; Barbaloin A; NSC 407305 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H22O9 |
| MW | 418.39 |
| CAS | 1415-73-2 |
| RTECS | LZ6520000 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow Powder. |
| Solubility | Soluble in DMSO or methanol (both 50mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | AFHJQYHRLPMKHU-OSYMLPPYSA-N |
| Smiles | OC1=C2C([C@@]([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)([H])C(C=C(CO)C=C4O)=C4C2=O)=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Aloin is a chemopreventive and antineoplastic agent. It is a cytotoxic against cancer cells. As a anticancer agent it inhibits Topoisomerase II alpha, induces apoptosis, targets High Mobility Group Box 1 (HMGB1) and inhibits angiogenesis. It has been shown to be a potent skin depigmenting agent, enhancing melanogenesis. It has been described as a tyroniase inhibitor. It regulates transglutaminase activity. In addition Aloin is an anti-inflammatory agent, inhibiting the NF-κB pathway, antitrypanosomal, iron chelating and microbiota modulating compound.
Product References
(1) C. Tan, et al.; Chin. Med. J. 115, 1859 (2002) | (2) A.Y. Esmat, et al.; Cancer Biol. Ther. 5, 97 (2006) | (3) A. Niciforovic, et al.; Cancer Biol. Ther. 6, 1200 (2007) | (4) E.J. Buenz; Toxicol. In Vitro 22, 422 (2008) | (5) A.H.A. Farooqi, et al.; J. Med. Aro. Plant. Sci. 31, 159 (2009) | (6) M.Y. Park, et al.; Biosci. Biotechnol. Biochem. 73, 828 (2009) | (7) S. Ravi, et al.; J. Exp. Sci. 2, 10 (2011) | (8) S. Hazrati, et al.; J. Med. Plants. Res. 6, 1834 (2012) | (9) S.A. Ali, et al.; Planta Med. 78, 767 (2012) | (10) Q. Pan, et al.; Cancer Cell Int. 13, 69 (2013) | (11) Y. Tewabe, et al.; BMC Vet. Res. 10, 61 (2014) | (12) A.Y. Esmat, et al.; Pharm. Biol. 53, 138 (2015) | (13) Y. Pengjam, et al.; Phytomedicine 23, 417 (2016) | (14) M.D. Boudreau, et al.; Toxicol. Sci. 158, 302 (2017) | (15) X. Luo, et al.; Molecules 23, E517 (2018) | (16) H. Tao, et al.; Drug Des. Devel. Ther. 13, 1221 (2019)