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Chemodex
Apigenin 7-glucoside
54
CHF
CHF 54.00
In stock
CDX-A0568-M0055 mgCHF 54.00
CDX-A0568-M01010 mgCHF 95.00
CDX-A0568-M02525 mgCHF 189.00
| Product Details | |
|---|---|
| Synonyms | Apigetrin; Cosmosiin; 4',5,7-Trihydroxyflavone 7-glucoside; 7-O-β-D-Glucopyranosylapigenin; Apigenin-7-O-β-D-glucoside; NSC 407303 |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H20O10 |
| MW | 432.38 |
| CAS | 578-74-5 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Light yellow powder. |
| Solubility | Soluble in DMSO (5mg/ml) or DMF. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | KMOUJOKENFFTPU-QNDFHXLGSA-N |
| Smiles | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(OC(C3=CC=C(O)C=C3)=CC4=O)=C4C(O)=C2)[C@@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Apigenin 7-glucoside is a flavonoid with anti-inflammatory, antioxidant, anticancer, anti-adipogenic and anxiolytic activities. It has been shown to inhibit LPS-induced nitric oxide production in RAW 264.7 cells or have hepatoprotective activity due to it's antioxidant activities, acting as scavengers of ROS. Apigenin 7-glucoside has been shown to have anti-proliferative activity, possible through cell cycle inhibition and consequently induce apoptosis. it also has the ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside has shown neuroprotective effects possibly by inhibiting neuroinflammation and its antioxidant activity. Apigenin-7-O-glucoside inhibits adipogenesis of 3T3-L1 preadipocytes at early stage of adipogenesis at high concentrations, by downregulating PPARγ and CEBP-α.
Product References
(1) J. Fuchs & R. Milbradt; Arzneimittelforschung 43, 370 (1993) | (2) Q.S. Zheng, et al.; Biomed. Environ. Sci. 18, 65 (2005) | (3) E. Nakazaki, et al.; Eur. J. Nutr. 52, 25 (2013) | (4) D. Kumar & Z.A. Bhat; Phytomedicine 21, 1010 (2014) | (5) N. Nasr Bouzaiene, et al.; Life Sci. 144, 80 (2016) | (6) H.S. Lim, et al.; J. Med. Food 19, 1032 (2016) | (7) Q. Sun, et al.; BBRC 498, 164 (2018) | (8) F. Hadrich & S. Sayadi; Lipids Health Dis. 17, 95 (2018) | (9) H. Guo, et al.; Biomed. Pharmacother. 109, 1978 (2019)