Chemodex

Amlodipine besylate

CHF 93.00
In stock
CDX-A0569-M01010 mgCHF 93.00
CDX-A0569-M05050 mgCHF 366.00
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Product Details
Synonyms 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate; Norvasc; Amdepin; Amdipin; Amlodin
Product Type Chemical
Properties
Formula

C20H25ClN2O5 . C6H5SO3H

MW 567.05
CAS 111470-99-6
RTECS US7967700
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in DMSO (40 mg/ml), chloroform, ethanol, methanol or water (5mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Smiles NCCOCC1=C(C(OCC)=O)C(C2=C(Cl)C=CC=C2)C(C(OC)=O)=C(C)N1.O=S(C3=CC=CC=C3)(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

Product References

(1) J.E. Arrowsmith, et al.; J. Med. Chem. 29, 1696 (1986) | (2) R.A. Burges, et al.; J. Cardiovasc. Pharmacol. 9, 110 (1987) | (3) G.A. Clavijo, et al.; Am. J. Hosp. Pharm. 51, 59 (1994) | (4) J. Yoshida, et al.; Eur. J. Pharmacol. 472, 23 (2003) | (5) R.P. Mason, et al.; Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003) | (6) H. Toba, et al.; Hypertens. Res. 28, 689 (2005)

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