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Chemodex
Amlodipine besylate
93
CHF
CHF 93.00
In stock
CDX-A0569-M01010 mgCHF 93.00
CDX-A0569-M05050 mgCHF 366.00
| Product Details | |
|---|---|
| Synonyms | 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate; Norvasc; Amdepin; Amdipin; Amlodin |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H25ClN2O5 . C6H5SO3H |
| MW | 567.05 |
| CAS | 111470-99-6 |
| RTECS | US7967700 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (40 mg/ml), chloroform, ethanol, methanol or water (5mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
| Smiles | NCCOCC1=C(C(OCC)=O)C(C2=C(Cl)C=CC=C2)C(C(OC)=O)=C(C)N1.O=S(C3=CC=CC=C3)(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Amlodipine is a long acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes. It acts at the voltage gated calcium channel of the CaV1 or L-type class. It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception. Amlodipine is also an antihypertensive agent that inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in peripheral vascular resistance, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the coronary arteries. Amlodipine has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.
Product References
(1) J.E. Arrowsmith, et al.; J. Med. Chem. 29, 1696 (1986) | (2) R.A. Burges, et al.; J. Cardiovasc. Pharmacol. 9, 110 (1987) | (3) G.A. Clavijo, et al.; Am. J. Hosp. Pharm. 51, 59 (1994) | (4) J. Yoshida, et al.; Eur. J. Pharmacol. 472, 23 (2003) | (5) R.P. Mason, et al.; Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003) | (6) H. Toba, et al.; Hypertens. Res. 28, 689 (2005)