Chemodex

BAPTA (free acid)

CHF 34.00
In stock
CDX-B0217-M250250 mgCHF 34.00
CDX-B0217-G0011 gCHF 102.00
CDX-B0217-G0055 gCHF 407.00
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Product Details
Synonyms 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
Product Type Chemical
Properties
Formula

C22H24N2O10

MW 476.4
CAS 85233-19-8
RTECS MC0423000
Source/Host Chemicals Synthetic
Purity Chemicals ≥98%
Appearance White to off-white powder.
Solubility Soluble in DMSO (20mg/ml) or DMF (20mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key FTEDXVNDVHYDQW-UHFFFAOYSA-N
Smiles O=C(O)CN(CC(O)=O)C1=C(OCCOC2=C(N(CC(O)=O)CC(O)=O)C=CC=C2)C=CC=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

BAPTA is a membrane-impermeable highly selective calcium chelator and is useful for manipulating extracellular Ca2+ levels, with 105-fold greater affinity for Ca2+ than for Mg2+. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives can be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). Key advantages of BAPTA include relative insensitivity toward intracellular pH change and fast release of calcium. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction, apoptotic cascades and neuroscience research.

Product References

(1) R.Y. Tsien, et al.; Biochemistry. 19, 2396 (1980) | (2) R.Y. Tsien, et al.; Annu. Rev. Biophys. Bioeng. 12, 91 (1983) | (3) G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) | (4) H. Kijima, et al.; J. Physiol. 403, 135 (1988) | (5) N. Tanabe, et al.; Neurosci. Lett. 92, 52 (1988) | (6) R.C. Hardie; Cell Calcium. 38, 547 (2005) | (7) R.W. Sabnis; Handbook of biological dyes and stains (2010)

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