Chemodex

(-)-Bicuculline methiodide

CHF 122.00
In stock
CDX-B0240-M02525 mgCHF 122.00
CDX-B0240-M100100 mgCHF 366.00
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Product Details
Synonyms N-Methylbicuculline iodide; 55950-07-7
Product Type Chemical
Properties
Formula

C21H20INO6

MW 509.29
CAS 40709-69-1
Purity Chemicals ≥95% (NMR)
Appearance White to off-white powder.
Solubility Soluble in water (10 mg/ml) or DMSO (30mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key HKJKCPKPSSVUHY-GRTNUQQKSA-M
Smiles C[N+]1(C)[C@@]([C@@]2([H])C(C=CC3=C4OCO3)=C4C(O2)=O)([H])C5=CC6=C(OCO6)C=C5CC1.[I-]
Shipping and Handling
Shipping AMBIENT
Short Term Storage +20°C
Long Term Storage +4°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
Description

(-)-Bicuculline methiodide is the N-methylated water-soluble derivative of the widely-employed ionotropic GABAA receptor antagonist (+)-Bicuculline. This prototypic, competitive GABAA receptor antagonist displaces GABA from the agonist binding site to prevent receptor activation. It also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents. Additionally it shows activity at SK calcium-activated potassium channels, nicotinic acetylcholine receptors and acetylcholinesterase. This compound reversibly and competitively blocks GABAA receptor mediated currents and is widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).

Product References

(1) R.W. Olsen, et al.; Brain Res. 102, 283 (1976) | (2) V. Seutin & S.W. Johnson; TiPS 20, 268 (1999) | (3) O. Chan, et al.; Diabetes 55, 1080 (2006) | (4) S. Kurt, et al.; Hear Res. 212, 224 (2006) | (5) G.A. Johnston; Br. J. Pharmacol. 169, 328 (2013) | (6) R.W. Olsen; Neuropharmacol. 136, 10 (2018)

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