D-Biotin p-nitrophenyl ester

CHF 81.00
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CDX-B0307-M100100 mgCHF 81.00
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Product Details
Synonyms (+)-Biotin 4-nitrophenyl ester; 4-Nitrophenyl (+)-biotinate; BNP; Biotin-ONp
Product Type Chemical


MW 365.4
CAS 33755-53-2
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance White to yellow powder.
Solubility Soluble in methanol (25mg/ml).
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Smiles O=C(OC1=CC=C([N+]([O-])=O)C=C1)CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

(+)-Biotin 4-nitrophenyl ester (Biotin-ONp) is a pre-activated biotin derivative, that is used as a biotinylation reagent in the modification of peptides, amino acids and proteins. Biotin-ONp is an effective and efficient tool for the introduction of biotin during solid phase synthesis, offering greater reactivity and higher solubility than Biotin-OSu. It may also be used to prepare biotinylated quinazoline derivatives. Recently, Biotin-ONp has been described as an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Product References

(1) P.S. Nelson, et al.; Nucleosid. Nucleotid. 5, 233 (1986) | (2) M. Wilchek & E.A. Bayer; Meth. Enzymol. 184, 123 (1990) | (3) R.L. Geahlen, et al.; Anal. Biochem. 202, 68 (1992) | (4) B. Baumeister, et al.; Int. J. Pept. Res. Therap. 11, 139 (2005) | (5) D.F.H. Winkler & P.L. McGeer; Proteomics 8, 961 (2008) | (6) S.-Y. Seo & T.W. Corson; Meh. Enzymol. 622, 347 (2019)

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