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Chemodex
Betulinic acid
108
CHF
CHF 108.00
In stock
CDX-B0402-M02525 mgCHF 108.00
| Product Details | |
|---|---|
| Synonyms | 3β-Hydroxy-20(29)-lupaene-28-oic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H48O3 |
| MW | 456.71 |
| CAS | 472-15-1 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (20mg/ml) or DMF (15mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QGJZLNKBHJESQX-FZFNOLFKSA-N |
| Smiles | O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5(C(O)=O)[C@]4([H])[C@H](C(C)=C)CC5)([H])C1(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Betulinic acid is a natural plant triterpenoid. It has been shown to have anticancer, apoptotic, anti-inflammatory, antiobesity, antimalarial and anti-HIC properties. It has been described as a potent DNA topoisomerase II inhibitor and proteasome activator. It is an agonist of the G protein-coupled bile acid receptor TGR5, which might be linked with its ability to alter gene expression and fatty liver development. Betulinic acid also reduces NF-κ signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.
Product References
(1) T. Fujioka, et al.; J. Nat. Prod. 57, 243 (1994) | (2) E. Pisha, et al.; Nat. Med. 1, 1046 (1995) | (3) Y. Kashiwada, et al.; J. Med. Chem. 39, 1016 (1996) | (4) Y. Takada & B.B. Aggarwal: J. Immunol. 171, 3278 (2003) | (5) H. Kasperczyk, et al.; Oncogene 24, 6945 (2005) | (6) S. Wada & R. Tanaka; Chem. Biodivers. 2, 689 (2005) | (7) L. Huang, et al.; FEBS Lett. 581, 4955 (2007) | (8) M.S. de Sa, et al.; Parasitol. Res. 105, 275 (2009) | (9) F.B. Mullauer, et al.; Anticancer Drugs 21, 215 (2010) | (10) C. Genet, et al.; J. Med. Chem. 53, 178 (2010) | (11) Y. Wan, et al.; Intern. Immunopharmacol. 17, 184 (2013) | (12) G.J. Zhao, et al.; PLoS One 8, e474782 (2013) | (13) K.D. Kim, et al.; Nutr. Metab. Cardiovasc. Dis. 29, 409 (2019) | (14) Y. Zheng, et al.; Oxid. Med. Cell Longev. 2019, 8781690 (2019) | (15) W. Liu, et al.; Am. J. Transl. Res. 11, 6952 (2019)