3-Cyanoumbelliferone

CHF 102.00
In stock
CDX-C0007-M100100 mgCHF 102.00
CDX-C0007-G0011 gCHF 242.00
CDX-C0007-G0055 gCHF 727.00
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Product Details
Product Type Chemical
Properties
Formula C10H5NO3
MW 187.15
CAS 19088-73-4
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (TLC)
Appearance Light red powder.
Solubility Soluble in alcohols or DMF.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key IJQYTHQDUDCJEQ-UHFFFAOYSA-N
Smiles OC1=CC=C2C=C(C#N)C(=O)OC2=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Phenolic dyes with high pKas - such as 7-hydroxycoumarin (often called umbelliferone) and the more common 7-hydroxy-4-methylcoumarin - are not fully deprotonated and therefore not fully fluorescent unless the pH of the reaction mixture is raised to above pH ~10. Thus, substrates derived from these fluorophores are seldom used for continuous measurement of enzymatic activity in solution or live cells. The similar 3-cyano-7-hydroxycoumarin and 6,8-difluoro-7-hydroxy-4-methylcoumarin have lower pKas, making them suitable for a broader range of applications. Moreover, the -trifluoromethylumbelliferone product has longer-wavelength spectra and stronger absorbance than -methylumbelliferone. Ether, ester and phosphate substrates derived from these phenolic dyes may be fluorescent but invariably exhibit shorter-wavelength absorption and emission spectra.

Product References

(1) I.N. White et al.; Anal. Biochem. 172(2), 304 (1988)

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