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Chemodex
Caffeic acid
27
CHF
CHF 27.00
In stock
CDX-C0024-G0055 gCHF 27.00
CDX-C0024-G02525 gCHF 108.00
| Product Details | |
|---|---|
| Synonyms | 3,4-Dihydroxybenzeneacrylic acid; 3,4-Dihydroxycinnamic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H8O4 |
| MW | 180.16 |
| CAS | 331-39-5 |
| RTECS | GD8950000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to light yellow powder. |
| Solubility | Soluble in ethanol (20mg/ml) or DMSO (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QAIPRVGONGVQAS-DUXPYHPUSA-N |
| Smiles | OC1=C(O)C=CC(/C=C/C(O)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Caffeic Acid is an endogenous phenolic phytochemical compound that inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis involved in immunoregulation, inflammation and allergy. Caffeic acid has antioxidant, immunomodulatory, antiviral, anti-inflammatory, neuroprotective anti-proliferative and anticancer activity. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets and to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk, Fyn kinase and xanthine oxidase. Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis.
Product References
(1) Y. Koshihara, et al.; Biochim. Biophys. Acta 792, 92 (1984) | (2) N. Kohyama, et al.; Biosci. Biotechnol. Biochem. 61, 347 (1997) | (3) I. Shureiqi, et al.; J. Natl. Cancer Inst. 92, 1136 (2000) | (4) F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004) | (5) F. Bailly, et al.; Curr. Med. Chem. 12, 1811 (2005) | (6) N.J. Kang, et al.; Carcinogenesis 30, 321 (2009) | (7) K.M.M. Espindola, et al.; Front. Oncol. 9, 541 (2009) (Review) | (8) N. Rajendra Prasad, et al.; Mol. Cell Biochem. 349, 11 (2011) | (9) M. Touaibia, et al.; Mini Rev. Med. Chem. 11, 695 (2011) (Review) | (10) S. Lee, et al.; PLoS One 9, e87708 (2014) | (11) F.A. Khan, et al.; J. Food Drug Anal. 24, 695 (2016) (Review) | (12) S. Habtemariam; Mini Rev. Med. Chem. 17, 667 (2017) (Review)