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Chemodex
5(6)-Carboxynaphthofluorescein
90
CHF
CHF 90.00
In stock
CDX-C0047-M02525 mgCHF 90.00
CDX-C0047-M100100 mgCHF 271.00
| Product Details | |
|---|---|
| Synonyms | CNF |
| Product Type | Chemical |
| Properties | |
| Formula | C29H16O7 |
| MW | 476.43 |
| CAS | 128724-35-6 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥90% (HPLC) |
| Appearance | Deep blue to deep violet powder. |
| Solubility | Soluble in DMSO or methanol (5mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | ANUHNEJUELPITC-UHFFFAOYSA-N |
| Smiles | OC(=O)c1ccc2c(c1)C(=O)OC23c4ccc5cc(O)ccc5c4Oc6c3ccc7cc(O)ccc67.OC(=O)c8ccc9C(=O)OC%10(c%11ccc%12cc(O)ccc%12c%11Oc%13c%10ccc%14cc(O)ccc%13%14)c9c8 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
5(6)-Carboxynaphthofluorescein (CNF) is a fluorescent NIR emitting pH indicator with red fluorescence at pH 9 (Spectral: Ex/Em: 598/668 nm). The fluorescence shifs to shorter wavelengths (Ex/Em: 512/567nm) at neutral or acidic pH environments. Spectral data: λex=512nm; λem=567nm (acid/neutral); λex=598nm; λem=668nm (basic). CNF shows good sensitivity in an alkaline pH range and it can be exploited in the construction of fiber-optic pH sensors. CNF has been used as an intravesicular pH probe for the colorimetric detection of activity, selectivity and cooperativity of ion channels. CNF has been used to design a luminescent probe for determination of pH, based on a Forster resonance energy transfer (FRET) system, combining a europium chelate as the donor and CNF as a pH sensitive acceptor. The FRET system enables referenced pH detection in an exceptional broad dynamic range from pH 3 to 9.
Product References
(1) A. Song, et al.; Anal. Chem. 69, 863 (1997) | (2) S.M. Butterfield, et al.; Org. Biomol. Chem. 7, 1784 (2009) | (3) R.J. Meier, et al.; Chem. Commun. 51, 6145 (2015) | (4) E. Poehler, et al., Anal. Bioanal. Chem. 408, 2927 (2016) | (5) D.A. Jankowska, et al.; Biosens. Bioelectr. 87, 312 (2017) | (6) S. Nevolova, et al.; Biotech. J. 14, 1800144 (2019)